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Is dark matter missing, or does gravity need modification?
Did replication or metabolism come first in the origin of life?
Is time fundamental or emergent?
Is quantum wave-function collapse physically real?
Is the universe spatially finite or infinite?
Are technological civilizations common or extremely rare?
Is aging mainly programmed or accumulated damage?
Is language ability mainly innate or learned from experience?
Does consciousness arise mainly from global broadcasting or information integration?
Can high-temperature superconductivity have one unifying mechanism?
Can free will exist if determinism is true?
Are there moral facts independent of human attitudes?
Is personal identity grounded in psychological or bodily continuity?
Is mathematics discovered or invented?
Do universals such as redness and roundness really exist?
Does knowledge require basic, non-inferential foundations?
Can the mind be fully reduced to physical processes?
Are you still the same person after perfect teleportation?
Is truth primarily correspondence with reality or success in inquiry?
Should future people’s interests count equally with present people’s?
Can machines have genuine subjective experience?
Does understanding require embodiment?
Do large language models understand, or merely predict?
Can high intelligence exist entirely without consciousness?
Can AI exhibit genuine creativity?
Do infectious diseases mainly come from germs or miasma?
Do continents move or remain essentially fixed?
Does combustion release phlogiston or combine with oxygen?
Does life arise spontaneously or from existing life?
Do meteorites come from space or terrestrial processes?